how is aspirin made from salicylic acid Salicylic acid

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Aspirin, a well-known pain reliever and fever reducer, has been used for over a century. It is a popular medication for mild to moderate pain, such as headaches and arthritis, among other conditions. The drug is called acetylsalicylic acid and contains salicylic acid, an organic acid commonly found in willow bark, among other plants. Salicylic acid is a chemical compound that is integral to the production of aspirin. It was first synthesized in 1838 by the Italian chemist Raffaele Piria. The compound was initially extracted from willow bark, which was used as a traditional medicine for thousands of years. Over time, the active ingredient in willow bark was identified as salicylic acid, which was eventually refined and purified for use in medications. The discovery of salicylic acid paved the way for the development of aspirin. In 1853, a French chemist named Charles Gerhardt synthesized acetylsalicylic acid, which was later refined and improved by German chemists Felix Hoffmann and Arthur Eichengrün. Aspirin became commercially available in 1899 and quickly became a popular medication for pain relief. Today, aspirin is not only a pain reliever but also used as a blood thinner. It has also been shown to have anti-inflammatory properties, which makes it effective in treating conditions such as rheumatoid arthritis and lupus. Research has also suggested that aspirin may play a role in cancer prevention. The synthesis of aspirin involves the reaction between salicylic acid and acetic anhydride. This process produces acetylsalicylic acid and acetic acid. The reaction is typically carried out in the presence of a catalyst, such as sulfuric acid, which speeds up the reaction and increases the yield of aspirin. When synthesized, aspirin is typically in the form of a white crystalline powder. The drug is then formulated into tablets, capsules, and other forms for easy consumption. As with any medication, it is important to follow the recommended dosage and speak with a healthcare provider before taking aspirin. In conclusion, aspirin is a widely used medication that has been a staple in healthcare for over a century. Its synthesis involves the reaction between salicylic acid and acetic anhydride, which produces acetylsalicylic acid. Aspirin is used for pain relief, fever reduction, and is also used as a blood thinner. The drug has anti-inflammatory properties and may play a role in cancer prevention. Always consult your healthcare provider before taking any medication.

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NASCENT & LATENT: Aspirin - A New Field For Cancer Treatment?

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Drug Metabolism In Medicinal Chemistry | PharmaFactz

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Synthesis Of Aspirin

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Salicylic Acid | Chemical Compound | Britannica

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Current Topics In Chemistry - Wade - Chapter 19

Current Topics in Chemistry - Wade - Chapter 19 faculty.missouri.eduaspirin acid salicylic chemical group synthesis esterification acetylsalicylic chemistry make phenol molecule hydroxyl properties prepared which diagram process phenolic

Aspirin salicylic metabolism hydrolysis phase hydrolytic. Current topics in chemistry. Salicylic acid